Ruifu Yang Selected Research

Plague (Bubonic Plague)

1/2021	Secretome and Comparative Proteomics of Yersinia pestis Identify Two Novel E3 Ubiquitin Ligases That Contribute to Plague Virulence.
1/2020	Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment.
7/2019	Hfq Globally Binds and Destabilizes sRNAs and mRNAs in Yersinia pestis.
1/2018	Successful transplantation of guinea pig gut microbiota in mice and its effect on pneumonic plague sensitivity.
12/2016	The Yersinia Type III secretion effector YopM Is an E3 ubiquitin ligase that induced necrotic cell death by targeting NLRP3.
7/2014	Transcriptomic response to Yersinia pestis: RIG-I like receptor signaling response is detrimental to the host against plague.
1/2014	IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-γ-activated macrophage programming.
6/2013	Live-attenuated Yersinia pestis vaccines.
1/2013	Identification of novel protein-protein interactions of Yersinia pestis type III secretion system by yeast two hybrid system.
11/2012	Acquisition of maternal antibodies both from the placenta and by lactation protects mouse offspring from Yersinia pestis challenge.

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Ruifu Yang Research Topics

Disease

27	Plague (Bubonic Plague) 01/2021 - 09/2004
21	Infections 12/2022 - 07/2004
4	Hypoxia (Hypoxemia) 10/2022 - 03/2015
4	Inflammation (Inflammations) 03/2015 - 03/2009
4	Severe Acute Respiratory Syndrome 04/2005 - 12/2003
3	COVID-19 01/2022 - 12/2020
2	Cardiomegaly (Heart Hypertrophy) 10/2022 - 01/2022
2	Cross Infection (Nosocomial Infection) 01/2022 - 08/2012
2	Neoplasms (Cancer) 01/2021 - 01/2015
2	Gastroenteritis 01/2019 - 01/2010
2	Carcinogenesis 01/2015 - 03/2009
2	Starvation 04/2008 - 05/2006
1	Body Weight (Weight, Body) 01/2022
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 11/2021
1	Reinfection 12/2020
1	Non-alcoholic Fatty Liver Disease 10/2019
1	Filoviridae Infections 01/2019
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2018
1	Septic Shock (Toxic Shock Syndrome) 01/2017
1	Necrosis 12/2016
1	Ebola Hemorrhagic Fever 03/2016
1	Mental Disorders (Mental Disorder) 01/2016
1	Tularemia 11/2015
1	Pneumonia (Pneumonitis) 08/2015
1	Abscess 01/2014
1	Tuberculosis (Tuberculoses) 10/2013
1	Brucellosis (Malta Fever) 12/2012
1	Type 2 Diabetes Mellitus (MODY) 10/2012
1	Dysbiosis 10/2012
1	Urinary Tract Infections (Urinary Tract Infection) 08/2012
1	Wound Infection (Wound Infections) 08/2012

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 05/2021 - 03/2005
10	VaccinesIBA 01/2014 - 12/2003
6	AntigensIBA 02/2013 - 03/2005
5	AntibodiesIBA 01/2022 - 04/2005
4	Type III Secretion SystemsIBA 01/2022 - 01/2013
4	RNA (Ribonucleic Acid)IBA 05/2021 - 01/2013
4	CytokinesIBA 01/2019 - 02/2009
3	Subunit VaccinesIBA 11/2012 - 09/2008
3	ImmunosorbentsIBA 02/2012 - 03/2005
3	EnzymesIBA 02/2012 - 03/2005
3	Indicators and Reagents (Reagents)IBA 01/2011 - 11/2009
3	Anti-Bacterial Agents (Antibiotics)IBA 03/2009 - 02/2005
2	Bile Acids and Salts (Bile Acids)IBA 10/2022 - 01/2022
2	Volatile Fatty AcidsIBA 10/2022 - 01/2022
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 03/2016
2	Amino Acids FDA Link 01/2022 - 03/2005
2	Viral RNAIBA 05/2021 - 12/2020
2	LigandsIBA 01/2021 - 07/2007
2	Ligases (Synthetase)IBA 01/2021 - 12/2016
2	EpitopesIBA 01/2020 - 07/2004
2	MicroRNAs (MicroRNA)IBA 03/2016 - 03/2009
2	Sirtuin 1IBA 03/2015 - 01/2015
2	Interleukin-12 (IL 12)IBA 03/2015 - 07/2014
2	Interleukin-4 (Interleukin 4)IBA 07/2014 - 01/2011
2	Pharmaceutical PreparationsIBA 10/2013 - 10/2006
2	DNA (Deoxyribonucleic Acid)IBA 10/2012 - 09/2004
2	Interferon-gamma (Interferon, gamma)IBA 02/2012 - 01/2011
2	Interleukin-2 (IL2)IBA 01/2011 - 02/2009
2	IronIBA 04/2008 - 05/2006
2	Antiviral Agents (Antivirals)IBA 06/2004 - 12/2003
1	Colistin (Coly-Mycin)FDA Link 12/2022
1	Carbapenems (Carbapenem Antibiotics)IBA 12/2022
1	PropionatesIBA 10/2022
1	PrebioticsIBA 01/2022
1	Lactose FDA LinkGeneric 01/2022
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022
1	Nonesterified Fatty Acids (NEFA)IBA 01/2022
1	Neutralizing AntibodiesIBA 01/2022
1	CholesterolIBA 11/2021
1	Complement System Proteins (Complement)IBA 05/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	Programmed Cell Death 1 ReceptorIBA 01/2021
1	UbiquitinIBA 01/2021
1	16S Ribosomal RNAIBA 12/2020
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 01/2020
1	Peptides (Polypeptides)IBA 01/2020
1	C-Type Lectins (C-Type Lectin)IBA 01/2019
1	thermostable direct hemolysinIBA 01/2019
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2019
1	ChemokinesIBA 01/2019
1	Cytokine Receptors (Cytokine Receptor)IBA 01/2019
1	bis(3',5')-cyclic diguanylic acidIBA 01/2018
1	Biological ProductsIBA 01/2018
1	Panton-Valentine leukocidinIBA 01/2017
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 12/2016
1	HMGB1 Protein (HMG1)IBA 12/2016
1	Therapeutic UsesIBA 01/2016
1	Biological Warfare AgentsIBA 11/2015
1	Coloring Agents (Dyes)IBA 08/2015
1	Aromatic Amino Acids (Aromatic Amino Acid)IBA 01/2015
1	Oncogene Proteins (Oncogene Protein)IBA 01/2015
1	Transcription Factors (Transcription Factor)IBA 01/2015
1	Interleukin-13IBA 07/2014
1	Interleukin-17 (Interleukin 17)IBA 01/2014
1	Butyrates (Butyrate)IBA 10/2012

Therapy/Procedure

2	Transplantation 10/2022 - 01/2018
2	Fecal Microbiota Transplantation 10/2019 - 01/2018
1	Surgical Instruments (Clip) 07/2019
1	Therapeutics 01/2015